Biological Functions of Heparan Sulfates.
نویسندگان
چکیده
منابع مشابه
Bioengineered heparins and heparan sulfates.
Heparin and heparan sulfates are closely related linear anionic polysaccharides, called glycosaminoglycans, which exhibit a number of important biological and pharmacological activities. These polysaccharides, having complex structures and polydispersity, are biosynthesized in the Golgi of animal cells. While heparan sulfate is a widely distributed membrane and extracellular glycosaminoglycan, ...
متن کاملHeterogeneity of heparan sulfates in human lung.
Heparan sulfates (HS), a class of glycosaminoglycans, are long linear complex polysaccharides covalently attached to a protein core. The HS molecules are made up of repeating disaccharides onto which modification patterns are superimposed. This results in a large structural heterogeneity and forms the basis of specific interactions of HS toward a vast array of proteins, including growth factors...
متن کاملHeparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the fo...
متن کاملCombinatorial Roles of Heparan Sulfate Proteoglycans and Heparan Sulfates in Caenorhabditis elegans Neural Development
Heparan sulfate proteoglycans (HSPGs) play critical roles in the development and adult physiology of all metazoan organisms. Most of the known molecular interactions of HSPGs are attributed to the structurally highly complex heparan sulfate (HS) glycans. However, whether a specific HSPG (such as syndecan) contains HS modifications that differ from another HSPG (such as glypican) has remained la...
متن کاملHeparins and heparan sulfates. Structure, distribution and protein interactions
Sulfated glycosaminoglycans are absent in protista, plantae and fungi. In the animal kingdom, the appearance of heparan sulfate coincides with the emergence of eumetazoa, which are animals that display true tissues. These compounds are ubiquitously found in the cell surface of all tissues and species. On the other hand, the distribution of heparin is scattered In honor of Prof. Carl P. Dietrich...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 1998
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.10.193